Aculip H Tablet (20 Tab)
Manufactured By: SHINE PHARMACEUTICALS LIMITED
Generic Name: AMITRIPTYLINE HYDROCHLORIDE Equivalent To Amitriptyline 12.5MG + CHLORDIAZEPOXIDE 5MG
Chlordiazepoxide is a benzodiazepine derivative used to treat severe anxiety, insomnia, anesthesia premedication, adjunct in management of seizures, muscle spasms in severe spastic disorders, alcohol withdrawal syndrome, sedation in minor surgical and medical procedures.
CNS drugs- (Anxiolytics)
Chlordiazepoxide is prescribed for the treatment of:
• Severe anxiety
• Insomnia
• Anesthesia premedication
• Adjunct in management of seizures
• Muscle spasms in severe spastic disorders
• Alcohol withdrawal syndrome
• Sedation in minor surgical and medical procedures
As advised by the physician.
According to the dosage forms the following routes of administration are available:
• Oral
• Parenteral
Chlordiazepoxide has anti-anxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a taming action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Precaution should be taken in
• Alcoholism
• Sedation
• Dependence
• Elderly
• Debilitated patients
• Liver or kidney dysfunction
• Avoid prolonged usage
Report to the physician if the patients are allergic to the active ingredients or any other drugs.
Acute pulmonary insufficiency, respiratory depression, patients with marked neuromuscular respiratory weakness, hypersensitivity to benzodiazepines, chronic psychosis, porphyria, pregnancy, lactation
Report to the physician immediately if the patients are having any of these following symptoms:
• Local irritation
• Increased susceptibility to e-coli bacteria
• Increased risk of genital ulceration
• Toxic shock syndrome
If allergic to any food, please consult with the physician.
Consumption of alcohol is not advisable.
Pregnancy Category: D
Please consult with physician during pregnancy & lactation.
Store at room temperature.
Amitriptyline, a tricyclic antidepressant, is used in treating depression, migraine, tension headaches, anxiety attacks and some schizophrenic symptoms. It is also known to reduce aggression and violent behaviour.
CNS drugs- (Tricyclic antidepressants)
Amitriptyline is prescribed for the treatment of:
• Depression
• Chronic pain
• Irritable bowel syndrome
• Sleep disorders
• Diabetic neuropathy
• Agitation and insomnia
• Migraine prophylaxis
As advised by the physician.
It may be taken with food to reduce irritation.
It should be taken orally.
Amitriptyline is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.
Precautions should be taken in case of:
• Angle-closure glaucoma
• Cardiac
• Kidney or liver diseases
• Epilepsy
Report to the physician if the patients are allergic to the active ingredients or any other drugs.
Hypersensitivity, use of monoamine oxidase inhibitors (MAOIs) within the last 14 days, concurrent usage with cisapride, pregnancy, lactation
Report to the physician immediately if the patients are having any of these following symptoms:
• Tachycardia
• Conduction disturbances
• Dry mouth
• Weight gain
• Sour or metallic taste
• Stomatitis
• Constipation
• Blurring of vision
• Urinary retention
• Fatigue
• Dizziness
• Weakness
• Tremors
• Headache
• Confusion
If allergic to any food, please consult with the physician.
Avoid excessive quantities of coffee or tea (caffeine).
Take with food to reduce irritation.
Consumption of alcohol is not advisable.
Pregnancy Category: C
Please consult with physician during pregnancy & lactation.
Store at room temperature.
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